Heart failure & cardiomyopathiesSecondary analysis
Outpatient worsening heart failure in transthyretin amyloid cardiomyopathy: findings from ATTRibute-CM
- Post-hoc exploratory analysis of the ATTRibute-CM phase 3 randomised trial
- modified ITT
Authors' conclusion
Outpatient worsening HF was associated with clinical outcomes in ATTR-CM. Acoramidis reduced the risk of outpatient worsening HF; effects emerged early and persisted throughout follow-up.
Study context
- Population
- Participants with transthyretin amyloid cardiomyopathy (ATTR-CM)modified ITT population
- Participants
- 611 participants
- Comparison
- Acoramidis vs placebo; outpatient worsening heart failure (HF) and clinical outcomes
Primary result
As reported in the abstract
Outpatient worsening HF (initiation/escalation of oral loop diuretics) and clinical outcomes · through month 30
Each group vs placeboHazard ratio (95% CI)
Outpatient worsening HFACM/recurrent CVH
1.95(1.51–2.51)
Outpatient worsening HFfirst CVH
2.78(1.95–3.95)
Outpatient worsening HFACM
1.64(1.14–2.36)
Outpatient worsening HFCV mortality
1.63(1.08–2.46)
Acoramidisfirst outpatient worsening HF; 41% risk reduction
0.59(0.46–0.75)
- Participants with outpatient worsening HF
- 287/611 (46.97%)
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| First outpatient worsening HF, early effect · day 30 · nominal significance first reached | 0.562 (0.317–0.998) | P = 0.0492 | |
| 0.20.5125Hazard ratio (log scale) |
First outpatient worsening HF, early effect · day 30
- Sustained nominal significance from day 134 through month 30
All-cause mortality (ACM)/recurrent cardiovascular hospitalization (CVH) and first CVH, adjusted for time-dependent first outpatient worsening HF · 30 months
- Acoramidis reduced the risk of ACM/recurrent CVH and first CVH vs placebo
Original publication
Outpatient worsening heart failure in transthyretin amyloid cardiomyopathy: findings from ATTRibute-CM. Eur J Heart Fail. Published 29 May 2026. doi:10.1093/ejhf/xuag177
Summarised from the published abstract; every number is checked against it