Prevention & lipidsCross-sectional study
Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry
- Cross-sectional study
- registry
- 50 countries
Authors' conclusion
Overweight and obesity are common in patients with HeFH and contribute to ASCVD risk from childhood, independent of LDL-C and lipid-lowering medication.
Study context
- Population
- Patients with heterozygous familial hypercholesterolaemia (HeFH), EAS FH Studies Collaboration registry, 50 countriesadults 29,265
- Participants
- 35,540 patients
- Exposure
- Obesity and overweight vs normal weight
- Outcome
- Prevalence of WHO-defined BMI categories and their association with prevalent atherosclerotic cardiovascular disease (ASCVD)
Main finding
As reported in the abstract
Overweight or obesity prevalence
Adults overweight or obese
52%
Children overweight or obese
27%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| CAD, stroke, PAD (obesity vs normal weight) — Obesity vs Normal weight | 9.28 (1.77–48.77) | |
| CAD, stroke, PAD (obesity vs normal weight) — Obesity vs Normal weight · CAD in adults | 2.35 (2.10–2.63) | |
| CAD, stroke, PAD (obesity vs normal weight) — Obesity vs Normal weight · stroke in adults | 1.65 (1.27–2.14) | |
| 0.050.21520Odds ratio (log scale) |
- CAD, stroke, PAD (obesity vs normal weight): CAD in children; adjusted for age, sex, lipids, lipid-lowering medication
- CAD, stroke, PAD (obesity vs normal weight): Adjusting for diabetes, hypertension and smoking modestly attenuated the associations
CAD, stroke, PAD (obesity vs normal weight)
- Less consistent association with PAD
- CAD prevalence increased progressively across BMI categories in children and adults
Age at FH diagnosis and lipid profile
- Median age at FH diagnosis in obese adults vs normal weight adults: older by
- 9 years
- Obesity associated with more atherogenic lipid profile independent of lipid-lowering medication
Original publication
Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry. Eur Heart J. Published 13 January 2025. doi:10.1093/eurheartj/ehae791
Summarised from the published abstract; every number is checked against it