Aortic & peripheral vascular disease
Oxidative stress–related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm: a Swedish population-based retrospective cohort study
Authors' conclusion
Our findings highlight the role of oxidative stress genetic variations and antioxidant vitamin intake in AAA.
Study context
- Population
- Malmö Diet and Cancer Study participants, Sweden
- Participants
- 25,252 participants
- Exposure
- Oxidative stress–related genetic variants and antioxidant vitamin intake
- Outcome
- Incidence of intact AAA and rupture (rAAA)
- Follow-up
- Median 24.3 years
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
- Cumulative incidence of intact abdominal aortic aneurysm (AAA)
- 1.6%
- Cumulative incidence of rAAA
- 0.3%
- NOX3 variant (rs3749930) and rAAA risk, males: aHR
- 2.49 (95% CI 1.36-4.35)
- NOX3 variant (rs3749930) and rAAA risk, overall: aHR
- 1.88 (95% CI 1.05-3.37)
- Higher riboflavin intake: reduction in intact AAA incidence
- 20%
- Higher folate intake: reduction in intact AAA incidence
- 19%
Observational data: associations, not effects.
Further findings
Intact AAA, by NOX3 genotype (interaction)
- Inverse association of riboflavin intake stronger in NOX3 variant carriers vs wild-type
- 60%
- Inverse association of vitamin D intake stronger in NOX3 variant carriers vs wild-type
- 66%
- P for interaction < 0.05
Intact AAA, by sex (interaction)
- Higher riboflavin intake: male-specific risk reduction
- 33%
- Higher vitamin B12 intake: female-specific risk increase
- 55%
- P for interaction < 0.05
Original publication
Oxidative stress–related genetic variation and antioxidant vitamin intake in intact and ruptured abdominal aortic aneurysm: a Swedish population-based retrospective cohort study. Eur J Prev Cardiol. Published 4 September 2023. doi:10.
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