Valvular & structural heart disease
Oxidized Phospholipids and Calcific Aortic Valvular Disease
Authors' conclusion
OxPL-apoB is a predictor of the presence, incidence, and progression of AVC and established AS, particularly in the setting of elevated Lp(a) levels, and may represent a novel therapeutic target for CAVD.
Study context
- Population
- MESA participants and participants with established aortic stenosis (AS) in 4 RCTsMESA + 4 RCTs
- Comparison
- OxPL-apoB and Lp levels
- Outcome
- Prevalence, incidence and progression of calcific aortic valve disease (CAVD) (AVC in MESA; annualized change in peak aortic valve jet velocity in AS)
Methodological detailsmultivariable ordinal regression, multivariable linear regression
- Multivariable ordinal regression
- Multivariable linear regression
Pooled result
As reported in the abstract
Prevalent AVC (MESA) · baseline
Odds ratio per SD (95% CI)
OxPL-apoB
1.19(1.07–1.32)
Lp(a)
1.13(1.01–1.27)
Further pooled results
| Outcome | ß (95% CI) |
|---|---|
| AS progression (annualized change in peak aortic valve jet velocity), meta-analysis | 0.07 (0.01–0.12) |
- AS progression (annualized change in peak aortic valve jet velocity), meta-analysis: evaluated together with Lp(a); only OxPL-apoB remained significant
Incident aortic valve calcium (AVC) (MESA) · 9.5 years
- Both OxPL-apoB and Lp(a) associated with incident AVC when evaluated individually
- Interaction P < 0.01
AS progression (annualized change in peak aortic valve jet velocity), meta-analysis
- Separately, both OxPL-apoB and Lp(a) associated with faster increase in peak jet velocity
Original publication
Oxidized Phospholipids and Calcific Aortic Valvular Disease. J Am Coll Cardiol. Published 15 November 2024. doi:10.
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