Heart failure & cardiomyopathiesResearch article
Oxygen utilization during moderate-intensity resistance and aerobic exercise in arrhythmogenic cardiomyopathy: the central role of the periphery
- invasive cardiopulmonary exercise testing
- right heart and radial artery catheterization
Authors' conclusion
Moderate-intensity isometric and dynamic resistance and aerobic exercise in ACM is mediated by a predominantly peripheral, rather than central, physiological stress in our small ACM sample. This may provide preliminary results for a physiological rationale for safe exercise in this population.
Study context
- Population
- Patients with arrhythmogenic cardiomyopathy (ACM)patients with ACM
- Participants
- Nineteen patients
- Comparison
- Isometric handgrip (IM-HG) vs bicep curl (BC) vs CYC-20 vs CYC-40
Main finding
As reported in the abstract
Exercise pulmonary hypertension (cardiac output to mean pulmonary artery slope >3 mmHg/L/min)
Did not occur; mean slope
0.67 mmHg/L/min
Further findings
Whole-body oxygen uptake (V̇O2)
- Increased significantly across all modes
- P < 0.001
Central oxygen delivery (O2D)
- Did not increase significantly during IM-HG or BC and rose only modestly during cycling
Peripheral O2 extraction and DmO2
- Increased significantly across all modalities
- P < 0.001
Dominance analysis of variance in V̇O2 pooled across all conditions
- DmO2
- 77%
- O2D
- 23%
Original publication
Oxygen utilization during moderate-intensity resistance and aerobic exercise in arrhythmogenic cardiomyopathy: the central role of the periphery. ESC Heart Fail. Published 5 June 2026. doi:10.1093/eschf/xvag163
Summarised from the published abstract; every number is checked against it