Heart failure & cardiomyopathiesCohort study
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure
- retrospective single-centre study
- exploratory multivariable logistic regression
Authors' conclusion
LISP referral identified very old patients with acute HF, advanced multidimensional vulnerability, higher NT-proBNP levels, and high short-term mortality. It should be interpreted as a clinician-assigned marker, not as a causal determinant of prognosis.
Study context
- Population
- Patients aged >65 years discharged after acute heart failure (HF) hospitalisation from a cardiogeriatric unit between 1 January and 24 September 2025patients analysed, 106 had LISP referral
- Participants
- 604 patients
Main finding
As reported in the abstract
Factors associated with LISP referral
Odds ratio (95% CI)P value
lower Activities of Daily Living score
0.45(0.37–0.55)
P < 0.001major neurocognitive disorders
2.98(1.73–5.13)
P < 0.001higher log-transformed discharge NT-proBNP
1.35(1.08–1.69)
P = 0.008lower SGLT2 inhibitor use among patients with LVEF >50%
0.49(0.27–0.88)
P = 0.017fewer discharge medications
0.88(0.79–0.97)
P = 0.011Observational data: associations, not effects.
Further findings
Survival · 6 months
- LISP referral associated with higher mortality and lower 6-month survival
- 47.6% vs. 79.5%
Baseline characteristics
- mean age
- 86.9 ± 7.1 years
- women
- 52%
Original publication
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure. ESC Heart Fail. Published 7 October 2026. doi:10.1093/eschf/xvag252
Summarised from the published abstract; every number is checked against it