Heart failure & cardiomyopathies
Parity and heart failure risk in diabetic women with coronary artery disease: a multicentre cohort study
Main finding · HF hospitalizationResult — go to the resultHazard ratio 1.41 95% CI 1.04–1.90Authors' conclusion
Among women with T2DM and CAD, high parity independently and outcome specifically predicted HF hospitalization, regardless of accumulated cardiovascular risk factors. Reproductive history should be considered in HF risk stratification even for high-risk women.
Study context
- Population
- Women with T2DM and coronary artery disease (CAD) from 70 hospitals in Japan, 2005–2022women with T2DM and CAD, median follow-up 2297 days
- Participants
- 2,314 women
- Exposure
- High parity compared with <5 births
- Outcome
- Heart failure (HF) hospitalization
- Follow-up
- Median 2297 days
Main finding
As reported in the abstract
Hazard ratio
1.41
95% CI 1.04–1.90
By group
≥5 birthsvs <5 births
HR 1.41 (95% CI 1.04–1.90)
Observational data: associations, not effects.
Further findings
Incidence, per 100 person-years
| Outcome | ≥5 births | <5 births | HR (95% CI) | |
|---|---|---|---|---|
| All-cause mortality · median follow-up 2297 daysAdjusted | 4.85 | 3.76 | 1.22 (.92-1.62) | |
| 0.512Hazard ratio (log scale) |
Acute myocardial infarction or stroke
- No associations were observed with acute myocardial infarction or stroke
Original publication
Parity and heart failure risk in diabetic women with coronary artery disease: a multicentre cohort study. ESC Heart Fail. Published 19 August 2026. doi:10.
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