Heart failure & cardiomyopathiesCohort study
Parity and heart failure risk in diabetic women with coronary artery disease: a multicentre cohort study
- multicentre retrospective cohort study
Authors' conclusion
Among women with T2DM and CAD, high parity independently and outcome specifically predicted HF hospitalization, regardless of accumulated cardiovascular risk factors. Reproductive history should be considered in HF risk stratification even for high-risk women.
Study context
- Population
- Women with T2DM and coronary artery disease (CAD) from 70 hospitals in Japan, 2005–2022women with T2DM and CAD, median follow-up 2297 days
- Participants
- 2,314 women
- Exposure
- high parity compared with <5 births
Main finding
Heart failure (HF) hospitalization · median follow-up 2297 days
Hazard ratio
1.41
95% CI 1.04–1.90
By group
≥5 births vs <5 births
HR 1.41 (95% CI 1.04–1.90)
As reported in the abstract
Observational data: associations, not effects.
Further findings
All-cause mortality · median follow-up 2297 days · adjusted
HR 1.22 (.92-1.62)
Acute myocardial infarction or stroke
- No associations were observed with acute myocardial infarction or stroke
Original publication
Parity and heart failure risk in diabetic women with coronary artery disease: a multicentre cohort study. ESC Heart Fail. Published 19 August 2026. doi:10.1093/eschf/xvag206
Summarised from the published abstract; every number is checked against it