Arrhythmias & electrophysiologyCohort study
Parity, infertility, age at first birth, and risk of atrial fibrillation: data from the HUNT study
- Prospective cohort study
- population-based
- linked with Medical Birth Registry of Norway
Authors' conclusion
Women with four or more births, or a history of infertility, or younger age at first birth have approximately a 20% higher risk of AF among women over 45 years old.
Study context
- Population
- Women aged ≥45 years in the HUNT study, Norway
- Participants
- 24,015 women
- Exposure
- Parity, infertility and age at first birth vs reference categories
- Outcome
- Verified incident AF
- Follow-up
- Median 12.8 years
Main finding
As reported in the abstract
Incident AF
Hazard ratio (95% CI)
Four or more births vs Two birthsmultivariable-adjusted
1.21(1.05–1.39)
Infertilitymultivariable-adjusted
1.20(1.02–1.42)
Age at first birth <20 years vs Age at first birth 20-29 yearsamong parous women; multivariable-adjusted
1.20(1.03–1.40)
- Participants who developed AF
- 1448 (6.0%)
Observational data: associations, not effects.
Original publication
Parity, infertility, age at first birth, and risk of atrial fibrillation: data from the HUNT study. Eur J Prev Cardiol. Published 1 July 2024. doi:10.1093/eurjpc/zwae215
Summarised from the published abstract; every number is checked against it