Coronary disease & ACSRandomised controlled trial
Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting
- Randomised controlled trial
- single-centre
Authors' conclusion
This randomized clinical trial found that partial cardiac denervation was an effective procedure to reduce the occurrence of POAF after isolated CABG without additional postoperative complications.
Study context
- Population
- Adults scheduled for isolated coronary artery bypass grafting (CABG) in China
- Participants
- 430 adults
- Comparison
- CABG plus partial cardiac denervation vs CABG only
- Primary endpoint
- Incidence of postoperative atrial fibrillation (POAF) (supraventricular arrhythmia lasting >30 seconds)
- Follow-up
- 6 days
Primary result
As reported in the abstract
Relative risk
0.57
95% CI 0.41–0.81
P = 0.001
By group
Intervention vs Control
RR 0.57 (95% CI 0.41–0.81); P = 0.001
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| POAF occurrence, Kaplan-Meier sensitivity analysis · sensitivity analysis | 0.53 (0.36–0.79) | P = 0.002 | |
| 0.20.5125Hazard ratio (log scale) |
Postoperative medical cost
- Reduced in the intervention group
Safety
Safety assessments
- No difference between the 2 groups
Original publication
Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting. JAMA Cardiol. Published 1 January 2025. doi:10.1001/jamacardio.2024.4639
Summarised from the published abstract; every number is checked against it