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Patient characteristics and prognostic importance of dialysis in infective endocarditis (IE)—A nationwide study

Am Heart JPublished

  • nationwide study
  • nationwide NIDUS registry
  • multivariable logistic regression
  • Kaplan-Meier methods and multivariable Cox models
+3 more
  • nationwide NIDUS registry
  • multivariable logistic regression
  • Kaplan-Meier methods and multivariable Cox models
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Authors' conclusion

Patients initiating dialysis during IE had an increased burden of traditional risk factors for AKI-with valve surgery representing the strongest associated risk factor for initiating dialysis. Patients initiating dialysis during IE had a markedly higher in-hospital mortality. Among survivors, higher associated mortality was confined to the early post-discharge period and diminished after 3 months.

Study context

Population
Dialysis-naive patients hospitalized with first-time left-sided IE in Denmark from 2016 to 2021patients with left-sided IE · received dialysis for acute kidney injury (AKI) 203 · did not receive dialysis 2,535
Participants
2,738 patients
Exposure
Patients grouped by whether they developed dialysis-requiring AKI
  • Dialysisn = 203
  • No dialysisn = 2,535reference

Main finding

As reported in the abstract

Valvular surgery

P < 0.01

Observational data: associations, not effects.

Further findings

OutcomeDialysisNo dialysisEstimate
In-hospital mortality · higher with dialysis37.9%16.5%HR 1.86 (95% CI 1.39–2.50)
Mortality among survivors · within 3 months12.0%9.0%higher with dialysis — HR 2.35 (95% CI 1.30–4.27)
Mortality among survivors · from 3 to 12 months · direction not stated in the abstract6.3%11.3%HR 0.89 (95% CI 0.41–1.93)

Independent factors associated with initiation of dialysis

chronic kidney disease, diabetes, liver disease, sepsis, valvular surgery, and infection with Staphylococcus aureus or Enterococcus species

Original publication

Patient characteristics and prognostic importance of dialysis in IE—A nationwide study. Am Heart J. Published 30 March 2026. doi:10.1016/j.ahj.2026.107435
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Summarised from the published abstract; every number is checked against it