Heart failure & cardiomyopathies
Patient Perspectives on a Polypill Strategy for Heart Failure With Reduced Ejection Fraction: A Convergent-Parallel Mixed Methods Study Embedded in a Randomized Clinical Trial
Authors' conclusion
In socioeconomically disadvantaged patients with heart failure with reduced ejection fraction, a polypill strategy demonstrated strong patient acceptability
Study context
- Population
- Participants and caregivers from the phase II POLY HF trial of an HFrEF polypill in Dallas, TX (socioeconomically disadvantaged)36 trial participants · 5 caregivers
- Participants
- 41 participants
- Primary endpoint
- Barriers and facilitators to polypill use across individual, interpersonal and systems levels; medication burden and polypill preferences
Methodological detailsfocus groups, brief surveys, directed content analysis (socioecological framework), Six focus groups with participants from both polypill and usual care arms
- Focus groups
- Brief surveys
- Directed content analysis (socioecological framework)
- Six focus groups with participants from both polypill and usual care arms
Primary result
As reported in the abstract
- Taking ≥6 medications
- 58%
- Reporting missed doses
- 50.0%
- Missed doses mainly due to forgetting
- 44%
- Interest in a polypill approach
- 88.6%
- Believed polypill would improve adherence
- 83%
Original publication
Patient Perspectives on a Polypill Strategy for Heart Failure With Reduced Ejection Fraction: A Convergent-Parallel Mixed Methods Study Embedded in a Randomized Clinical Trial. Circ Popul Health Outcomes. Published 10 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it