Coronary disease & ACSCohort study
Patients with angina and non-obstructive coronary artery disease undergoing comprehensive invasive coronary function testing: long-term clinical outcomes
- Registry-based cohort study
Authors' conclusion
The long-term risk of MACE-EA is doubled in ANOCA patients with CFT-confirmed CVDys compared to normal CFT results.
Study context
- Population
- Patients with angina and non-obstructive CAD undergoing clinically indicated invasive coronary function test (CFT) (NL-CFT registry), 2019–20241,252 with complete follow-up
- Participants
- 1,355 patients
- Exposure
- Coronary vasomotor dysfunction (CVDys) vs normal CFT
- Outcome
- MACE-EA: all-cause death, ACS, stroke/TIA, revascularization, repeat angiography without intervention, HF hospitalizations, unplanned hospitalizations or ED visits due to angina
- Follow-up
- Mean 33±13 months
Main finding
As reported in the abstract
MACE-EA
P < 0.001
Observational data: associations, not effects.
Further findings
Abnormal CFT (prevalence)
- CFT abnormal; vasospasm the most prevalent endotype
- 79.8%
Death, MI, stroke or revascularization
- Low and comparable between the groups
Original publication
Patients with angina and non-obstructive coronary artery disease undergoing comprehensive invasive coronary function testing: long-term clinical outcomes. Eur Heart J. Published 31 August 2026. doi:10.1093/eurheartj/ehag649
Summarised from the published abstract; every number is checked against it