Arrhythmias & electrophysiology
Patterns of comorbidities, clinical course, and impact of the ABC Pathway for Integrated Care in patients with atrial fibrillation: a report from the prospective Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) Registry
Authors' conclusion
Different clinical phenotypes can be identified in Asian AF patients, with specific patterns of comorbidities and different risks of adverse events. Full ABC pathway adherence was associated with improved outcomes, regardless of the clinical phenotype.
Study context
- Population
- Elderly Chinese patients with atrial fibrillation (AF)AF patients, 2654 with available information to assess the ABC pathway
- Participants
- 4,765 patients
- Exposure
- Compared to the ‘low complexity’ class
- Outcome
- Composite of:
- All-cause death
- Major adverse cardiovascular (CV) events
- Follow-up
- 1-year follow-up
Methodological detailslatent class analysis
- Latent class analysis
Main finding
As reported in the abstract
Each group vs low complexityAdjusted odds ratio (95% CI)
High complexity
3.20(2.21–4.66)
Heart failure
1.50(1.04–2.17)
Observational data: associations, not effects.
Further findings
Adverse events with ABC pathway adherence
| Comparison | aOR (95% CI) | |
|---|---|---|
| ABC pathway adherenceLower risk of adverse events · interaction analysis | 0.37 (0.20–0.65) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Phenotype distribution
- Adverse events with ABC pathway adherence — Beneficial effect similar across different clinical phenotypes
- Pint = 0.122
ABC pathway adherence
- Adherent, among 2654 patients with available information
- 1094 (41.2%)
Original publication
Patterns of comorbidities, clinical course, and impact of the ABC Pathway for Integrated Care in patients with atrial fibrillation: a report from the prospective Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) Registry. Eur Heart J Qual Care Clin Outcomes. Published 15 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it