Heart failure & cardiomyopathiesSecondary analysis
Patterns of Left Ventricular Regional Wall Motion Abnormalities After Brain Death and Their Clinical Significance
- Secondary analysis of the Donor Heart Study
- machine learning (k-means clustering)
Authors' conclusion
Left ventricular dysfunction after brain death exhibits distinct RWMA phenotypes, which differ in terms of selected biomarkers and LVEF, but not in recipient survival of the hearts accepted for transplantation.
Study context
- Population
- Potential heart donors after brain death with any regional wall motion abnormality (RWMA) on TTE913 initial TTEs analysed
- Participants
- 4,333 donors
- Comparison
- RWMA phenotypes after brain death
- Focal basal septal (FBS)n = 500
- Basal and midventricularn = 311
- Apicaln = 66
- Global hypokinesisn = 36
- Primary endpoint
- RWMA phenotypes and their associations with donor characteristics, heart use and recipient survival
Primary result
As reported in the abstract
RWMA phenotypes
| Group | Heart acceptance for transplantation |
|---|---|
| FBS | 68% |
- FBS had the highest donor heart acceptance
- 68%
Further findings
Left ventricular ejection fraction (LVEF) on subsequent TTEs
- All phenotypes showed significant improvement in LVEF (314 donors with subsequent TTE)
Recipient survival (accepted hearts)
- No significant differences by RWMA phenotype
Original publication
Patterns of Left Ventricular Regional Wall Motion Abnormalities After Brain Death and Their Clinical Significance. JACC Heart Fail. Published 26 June 2025. doi:10.1016/j.jchf.2025.102511
Summarised from the published abstract; every number is checked against it