Valvular & structural heart disease
Patterns of Postdischarge Heart Failure, Ischemic, and Bleeding Events After Transcatheter Aortic Valve Replacement
Authors' conclusion
Among patients who experienced a first postdischarge event after TAVR, major bleeding occurred earlier than HF hospitalization or ischemic events. Once a first postdischarge event occurred, subsequent all-cause mortality was high across the 3 event groups. These findings suggest that event timing should be considered and careful clinical reassessment may be warranted when a first postdischarge event occurs after TAVR.
Study context
- Population
- Patients with severe aortic stenosis who underwent transcatheter aortic valve replacement (TAVR)
- Participants
- 988 patients
- Exposure
- Patients grouped according to the first clinical event after discharge: Heart failure (HF) hospitalization, ischemic events, major bleeding, or the event-free group
- HF hospitalizationn = 80
- Ischemic eventsn = 32
- Major bleedingn = 53
- Event-free groupn = 823
- Outcome
- Any of these events:
- HF hospitalization
- Ischemic events
- Major bleeding
- Follow-up
- Median 665 days after discharge
Main finding
As reported in the abstract
Patients experiencing any of these events
165 patients
16.7%
Observational data: associations, not effects.
Further findings
First postdischarge events · median follow-up of 665 days after discharge
| Outcome | HF hospitalization | Ischemic events | Major bleeding | Event-free group |
|---|---|---|---|---|
| All-cause mortality after the first event · 1 year after the first event | 31.5% | 30.4% | 25.4% | — not stated in the abstract |
— not stated in the abstract
Timing of first postdischarge event
- Among patients with a first postdischarge event, major bleeding occurred earliest among the 3 event groups
Original publication
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