Valvular & structural heart disease
Percutaneous Coronary Intervention in Frail Patients Undergoing Transcatheter Aortic Valve Replacement: A NOTION-3 Substudy
Primary result · MACE in nonfrail patientsResult — go to the resultHazard ratio 0.42 95% CI 0.25–0.69Authors' conclusion
In nonfrail patients with CAD undergoing TAVR, PCI lowered the risk for MACE, all-cause mortality, and MI compared to conservative treatment. In frail patients, PCI increased bleeding without clinical benefit.
Study context
- Population
- Patients with coronary artery disease (CAD) and severe AS undergoing transcatheter aortic valve replacement (TAVR), by frailty status130 (32%) frail
- Participants
- 407 patients
- Comparison
- Percutaneous coronary intervention (PCI) vs conservative treatment in TAVR patients, by frailty
- Primary endpoint
- Composite of:
- All-cause mortality
- MI
- Urgent coronary revascularization (MACE)
Methodological detailsinternational, open-label, superiority, post hoc frailty assessment
- International
- Open-label
- Superiority
- Post hoc frailty assessment
Primary result
MACE in nonfrail patients · median follow-up 2 years (Q1-Q3: 1-4 years)
Hazard ratio
0.42
95% CI 0.25–0.69
P < 0.001
By group
PCIvs Conservative treatment
HR 0.42 (95% CI 0.25–0.69); P < 0.001
As reported in the abstract
Further findings
Components of major adverse cardiac events (MACE) in nonfrail patients
- PCI reduced death of any cause
- P = 0.019
- PCI reduced myocardial infarction (MI)
- P = 0.004
- PCI reduced urgent revascularization
- P = 0.005
Safety
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Bleeding events in frail patientsMore bleeding with PCI | 2.51 (1.23–5.11) | P = 0.011 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Percutaneous Coronary Intervention in Frail Patients Undergoing Transcatheter Aortic Valve Replacement: A NOTION-3 Substudy. JACC Cardiovasc Interv. Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →