Acute cardiac care & resuscitationSecondary analysis
Percutaneous Coronary Intervention in Multivessel Disease and Infarct-Related Cardiogenic Shock
- Secondary analysis of the DanGer Shock randomised trial
- exploratory substudy
- multicentre
- as-treated analysis
Authors' conclusion
Immediate multivessel PCI was associated with 60% lower odds of all-cause mortality compared with culprit-only PCI.
Study context
- Population
- STEMI-related cardiogenic shock with multivessel disease (≥1 nonculprit stenosis ≥70%), excluding comatose patients resuscitated from cardiac arrest and isolated left main culpritof 355 in DanGer Shock
- Participants
- 221 participants
- Comparison
- Immediate multivessel percutaneous coronary intervention (PCI) vs culprit-only PCI
- Immediate multivessel PCIn = 103
- Culprit-only PCIn = 118reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 180 days
Primary result
As reported in the abstract
median follow-up 45 days (Q1-Q3: 2-180 days)
Adjusted odds ratio
0.40
95% CI 0.19–0.83
Events by treatment group
Immediate multivessel PCI vs Culprit-only PCI
adjusted OR 0.40 (95% CI 0.19–0.83)
Secondary outcomes
Renal replacement therapy and acute kidney injury
- Immediate multivessel PCI not associated with the secondary outcomes
Original publication
Percutaneous Coronary Intervention in Multivessel Disease and Infarct-Related Cardiogenic Shock. JACC Cardiovasc Interv. Published 22 September 2025. doi:10.1016/j.jcin.2025.07.035
Summarised from the published abstract; every number is checked against it