Arrhythmias & electrophysiology
Percutaneous left atrial appendage closure following catheter ablation therapy of atrial fibrillation: outcomes stratified by bleeding risk – a sub-analysis of the OPTION study
Authors' conclusion
Regardless of bleeding risk, LAAC is comparable to OAC in stroke protection while demonstrating greater freedom from bleeding in a post-ablation AF population, even in patients with low HAS-BLED scores.
Study context
- Population
- Patients with atrial fibrillation (AF) and high stroke risk undergoing catheter ablation, stratified by HAS-BLED score (0, 1, 2, ≥3)randomized 1:1
- Participants
- 1,600 patients
- Comparison
- Left atrial appendage closure (LAAC) vs oral anticoagulation (OAC) after catheter ablation of AF
- Primary endpoint
- Primary effectiveness (all-cause death/stroke/systemic embolism) and safety (bleeding composite) endpoints by HAS-BLED subgroup
Methodological detailspre-specified sub-analysis, stratified by HAS-BLED score
- Pre-specified sub-analysis
- Stratified by HAS-BLED score
Primary result
As reported in the abstract
Primary safety bleeding events by HAS-BLED subgroup
LAAC vs OACHazard ratio (95% CI)
HAS-BLED 0 (n = 265)
0.25(0.20–0.50)
HAS-BLED 1 (n = 890)
0.41(0.27–0.61)
Original publication
Percutaneous left atrial appendage closure following catheter ablation therapy of atrial fibrillation: outcomes stratified by bleeding risk – a sub-analysis of the OPTION study. Europace. Published 2 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →