Heart failure & cardiomyopathiesCohort study
Performance of a multi-sensor implantable defibrillator algorithm for heart failure monitoring in the presence of atrial fibrillation
- Observational cohort study
- multicentre
- propensity-score matched (2:1)
Authors' conclusion
Patients received more alerts during periods of AF. The ability of the algorithm to identify increased risk of HF events was confirmed during AF, despite a lower IN/OUT-of-alert incidence rate ratio in comparison with non-AF periods and non-AF patients.
Study context
- Population
- ICD patients with HeartLogic heart failure (HF) monitoring activated, 26 centres
- Participants
- 568 patients · 26 centres
- Exposure
- HeartLogic performance during atrial high-rate episode (AHRE) burden ≥20 h/day (atrial fibrillation (AF)) vs <1 h/day periods, and vs matched non-AHRE patients
- AHREn = 53
- Matched non-AHREn = 106reference
Main finding
As reported in the abstract
AHRE
1.2 (95% CI: 1.0-1.5)/patient-year
Alert rate, AHRE burden <1 h/day · Alert rate, AHRE burden ≥20 h/day 2.0 (95% CI: 1.5-2.6)/patient-year · HF hospitalization rate, IN-alert 0.34 (95% CI: 0.15-0.69)/patient-year · HF hospitalization rate, OUT-of-alert 0.06 (95% CI: 0.02-0.14)/patient-year
Matched non-AHRE
0.29 (95% CI: 0.12-0.60)/patient-year
HF hospitalization rate, IN-alert · HF hospitalization rate, OUT-of-alert 0.04 (95% CI: 0.02-0.08)/patient-year
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it