Prevention & lipidsCohort study
Performance of the American Heart Association’s PREVENT Equations Among Disaggregated Racial and Ethnic Subgroups
- Retrospective cohort study
- electronic health record-based
Authors' conclusion
The PREVENT equations appropriately predicted risk in contemporary diverse Asian and Hispanic subgroups with modest variation in performance across disaggregated subgroups.
Study context
- Population
- Primary care patients aged 30–79 years, Sutter Health, Northern California, 2010–2023, free from Cardiovascular Disease (CVD) at baseline
- Participants
- 361,778 patients
- Exposure
- PREVENT equations performance across racial and ethnic subgroups
- Asiann = 81,424
- Hispanicn = 40,897
- Outcome
- CVD events (ICD codes as in the PREVENT derivation); PREVENT model performance (C statistic, calibration slope)
- Follow-up
- Mean 8.1 years
Main finding
As reported in the abstract
Total CVD: discrimination and calibration
| Group | C statistic | Calibration slope |
|---|---|---|
| Asian | 0.83 (95% CI, 0.82-0.84) | 0.84 (95% CI, 0.78-0.90) |
| Hispanic | 0.80 (95% CI, 0.79-0.81) | 1.02 (95% CI, 0.94-1.10) |
- Asian subgroups: C statistic from Filipino to Asian Indian
- 0.79 (95% CI, 0.77-0.81) to 0.85 (95% CI, 0.83-0.87)
- Hispanic subgroups: C statistics similar, total CVD
- between 0.80 and 0.82
Observational data: associations, not effects.
Further findings
Overall CVD events · mean follow-up 8.1 years
- CVD events
- 22 648 (6.3%)
ASCVD and HF PREVENT equations
- Small differences in performance among racial and ethnic groups and subgroups
Original publication
Performance of the American Heart Association’s PREVENT Equations Among Disaggregated Racial and Ethnic Subgroups. JAMA Cardiol. Published 1 September 2025. doi:10.1001/jamacardio.2025.1865
Summarised from the published abstract; every number is checked against it