Prevention & lipidsCohort study
Performance of the American Heart Association’s PREVENT risk score for cardiovascular risk prediction in a multiethnic population
- Retrospective cohort study
- nationwide
- multiethnic
Authors' conclusion
Among US veterans, the PREVENT equations accurately estimated CVD and ASCVD risk with some variability across race and ethnicity groups and outperformed PCEs for ASCVD risk prediction.
Study context
- Population
- US veterans aged 30–79 years, multiethnic nationwide sample407,342 total CVD events
- Participants
- 2,500,291 veterans
- Exposure
- PREVENT ASCVD vs pooled cohort equations (PCEs) for ASCVD risk prediction
- Outcome
- Discrimination (C-index) and calibration of prediction of total CVD (fatal/nonfatal MI, stroke or HF), ASCVD (fatal/nonfatal MI or stroke) and HF
- Follow-up
- Median 5.8 (IQR 3.1-8.3) years
Main finding
As reported in the abstract
Total CVD discrimination (C-index), PREVENT-CVD
| Group | Concordance index (C-index), overall | C-index, Asian, Native Hawaiian or Pacific Islander | C-index, Hispanic | C-index, non-Hispanic Black | C-index, non-Hispanic White | Calibration slope, PREVENT-CVD | Calibration slope, PREVENT-ASCVD | Calibration slope, ASCVD (overprediction) |
|---|---|---|---|---|---|---|---|---|
| PREVENT | 0.65 (95% CI 0.65-0.65) | 0.70 (95% CI 0.69-0.71) | 0.70 (95% CI 0.69-0.70) | 0.68 (95% CI 0.68-0.69) | 0.65 (95% CI 0.64-0.65) | 1.09 (SE 0.04) | 1.15 (SE 0.04) | |
| PCEs | 0.51 (SE 0.06) |
Observational data: associations, not effects.
Original publication
Performance of the American Heart Association’s PREVENT risk score for cardiovascular risk prediction in a multiethnic population. Nat Med. Published 4 July 2025. doi:10.1038/s41591-025-03789-2
Summarised from the published abstract; every number is checked against it