Heart failure & cardiomyopathies
Performance of the quadripolar CRT-defibrillator (CRT-D) system: Five-year results from the Quadripolar Pacing Post-Approval Study
Authors' conclusion
The quadripolar CRT-D system with the Quartet 1458Q LV lead exhibited low rates of complications and stable electrical performance through 5 years of follow-up and suggested a higher 5-year survival rate compared with traditional CRT systems.
Study context
- Population
- Patients indicated for a CRT-D system
- Participants
- 1,970 patients71 sites
- Outcome
- Freedom from quadripolar CRT-D system-related complications; freedom from Quartet 1458Q LV lead-related complications; mean programmed pacing capture threshold
- Follow-up
- Through 5 years (threshold at 5 years)
Methodological detailssingle-arm, multicentre (71 sites), Follow-up every 6 months after implantation for 5 years
- Single-arm
- Multicentre (71 sites)
- Follow-up every 6 months after implantation for 5 years
Main finding
As reported in the abstract
Freedom from quadripolar CRT-D system-related complications through 5 years
89.7%
Freedom from Quartet 1458Q left ventricular (LV) lead-related complications through 5 years
95.7%
Mean LV pacing capture threshold at 5 years (V, ± spread as printed)
1.52 ± 1.01 V
Observational data: associations, not effects.
Further findings
Successful implantation of quadripolar CRT-D system
- Successfully implanted
- 97.2%
5-year survival
- 5-year survival rate
- 67.4%
LV lead-related complications
- Participants with LV lead-related complications
- 3.49%
- Overall LV lead complication rate
- 0.0122 event per patient-year
Safety
| Outcome | Values |
|---|---|
| LV lead-related complications · 5 years | Quadripolar CRT-D 3.49% · Overall LV lead complication rate 0.0122 event per patient-year |
Original publication
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