Pericardial Disease-Related Mortality in the United States: A Comprehensive Analysis of 1999 to 2019 Trends
Authors' conclusion
These findings underscore a resurgence in PD-related mortality
Study context
- Population
- US adults aged ≥25 years with pericardial disease-related death, 1999–2019
- Participants
- 87,285 pericardial disease (PD)-related deaths
- Outcome
- PD-related AAMR trends
- Follow-up
- 1999 to 2019
Methodological detailsdescriptive analysis, death certificate data (CDC WONDER), joinpoint regression
- Descriptive analysis
- Death certificate data (CDC WONDER)
- Joinpoint regression
Main finding
As reported in the abstract
AAMR trend
- AAMR 1999
- 2.36
- AAMR 2012
- 1.70
- Annual percentage change 1999–2012
- −2.74% (P < 0.001)
- AAMR 2019
- 2.04
- Annual percentage change 2012–2019
- +2.94% (P < 0.001)
Observational data: associations, not effects.
Further findings
Demographic and regional variation
- Higher mortality among males, older adults (≥65 years) and non-Hispanic Black or African American individuals
- Western region had the highest AAMR
- Rural areas slightly higher mortality than urban areas after 2012
Original publication
Pericardial Disease-Related Mortality in the United States: A Comprehensive Analysis of 1999 to 2019 Trends. JACC Adv. Published 15 September 2025. doi:10.
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