Arrhythmias & electrophysiology
Pericardial Effusion After Left Atrial Appendage Closure: Timing, Predictors, and Clinical Impact
Authors' conclusion
In this large LAAC registry, PE was observed in <1 in 20 patients and usually occurred within 6 hours after procedure. The majority of early PEs were clinically relevant and occurred in the Amplatzer Cardiac Plug/Amulet procedures. Independent predictors included the use of double-closure devices, female sex, OAC at baseline, and advanced age.
Study context
- Population
- Consecutive patients undergoing percutaneous left atrial appendage closure (LAAC), 2009–2022
- Participants
- 1,023 attempted LAAC procedures
- Outcome
- Frequency, timing, predictors and clinical impact of pericardial effusion after LAAC
- Follow-up
- 1-year follow-up
Methodological detailsconsecutive patients, imaging core laboratory adjudication
- Consecutive patients
- Imaging core laboratory adjudication
Main finding
As reported in the abstract
Pericardial effusion
- Pericardial effusion (PE) overall
- 44 (4.3%)
- Early PE (≤7 days)
- 34 (3.3%)
- Late PE (8-365 days)
- 10 (0.9%)
- PE within 6 hours after LAAC
- n = 25, 56.8%
- Clinically relevant PE
- n = 28, 63.6%
Observational data: associations, not effects.
Further findings
Independent predictors of early PE
| Adjusted OR (95% CI) | ||
|---|---|---|
| Double-closure devices | 8.20 (1.09–61.69) | |
| Female sex | 3.41 (1.50–7.73) | |
| OAC at baseline | 2.60 (1.11–6.09) | |
| Advanced age | 1.07 (1.01–1.23) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Independent predictors of overall PE
- Female sex and oral anticoagulation (OAC) at baseline remained independent predictors
Original publication
Pericardial Effusion After Left Atrial Appendage Closure: Timing, Predictors, and Clinical Impact. JACC Cardiovasc Interv. Published 22 May 2024. doi:10.
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