Cardio-oncology & otherCohort study
Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study
- Matched cohort study
- nationwide
- population-based
- individually matched on age and year of conception/delivery
- sibling comparison
Authors' conclusion
Women with PND are at higher risk of CVD in middle adulthood.
Study context
- Population
- Women in Sweden, perinatal depression (PND) diagnosed 2001–14, followed up to 2020matched cohort
- Participants
- 55,539 vs 545,567
- Exposure
- PND vs matched unaffected women
- PNDn = 55,539
- Unaffectedn = 545,567reference
- Outcome
- Any and type-specific CVD
- Follow-up
- Up to 20 years (mean 10.4, SD 3.6)
Main finding
CVD · up to 20 years
Adjusted hazard ratio
1.36
95% CI 1.31–1.42
Events by group
PND vs Unaffected
adjusted HR 1.36 (95% CI 1.31–1.42)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| CVD, sibling comparison (PND vs sisters) · vs their sisters; 20% higher risk | 1.20 (1.07–1.34) | |
| 0.512Adjusted hazard ratio (log scale) |
Cardiovascular disease (CVD), by history of psychiatric disorder (subgroup)
- Results most pronounced in women without a history of psychiatric disorder
- P for interaction < 0.001
- interaction P < .001
CVD subtypes
- Association observed for all CVD subtypes; hypertensive disease HR
- 1.50 (1.41-1.60) (95% CI)
- Ischaemic heart disease HR
- 1.37 (1.13-1.65) (95% CI)
- HF HR
- 1.36 (1.06-1.74) (95% CI)
Original publication
Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study. Eur Heart J. Published 18 June 2024. doi:10.1093/eurheartj/ehae170
Summarised from the published abstract; every number is checked against it