Cohort study
Periodontitis, epicardial adipose tissue and coronary events: the Swedish Cardiopulmonary Bioimage Study
- Cohort study
- population-based
- register-linked
Authors' conclusion
Severe periodontitis is positively associated with subclinical coronary atherosclerosis, EAT alterations reflecting inflammatory activity, and CHD event incidence.
Study context
- Population
- SCAPIS participants linked to national dental and coronary heart disease (CHD) registers6% severe periodontitis
- Participants
- 29,056 participants
- Exposure
- Severe periodontitis vs no severe periodontitis
- Severe periodontitisn = 1,809
- Outcome
- Mediation of the periodontitis–incident CHD association by subclinical atherosclerosis (coronary artery calcium scores (CACS), segment involvement scores (SIS))
Main finding
Incident CHD events
Hazard ratio
1.42
95% CI 1.03–1.97
Periodontitis vs No severe periodontitis
HR 1.42 (95% CI 1.03–1.97)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Severe CACS (≥301) · strongest without concomitant dental caries | 1.69 (1.39–2.06) | |
| Severe SIS (>4 segments) · strongest without concomitant dental caries | 1.40 (1.17–1.67) | |
| 0.512Odds ratio (log scale) |
| Outcome | β (HU) (95% CI) |
|---|---|
| EAT attenuation · lower attenuation | −0.27 (−0.48 to −0.05) |
Original publication
Periodontitis, epicardial adipose tissue and coronary events: the Swedish Cardiopulmonary Bioimage Study. Eur Heart J. Published 5 August 2026. doi:10.1093/eurheartj/ehag569
Summarised from the published abstract; every number is checked against it