Aortic & peripheral vascular diseaseRandomised controlled trial
Periodontitis treatment and progression of carotid intima-media thickness: a randomized trial
- Randomised controlled trial
- single-blind
- single-centre
Authors' conclusion
IPT led to favourable structural changes in the vascular phenotype, underscoring the impact of PD on cardiovascular health
Study context
- Population
- Consecutive, otherwise healthy participants with periodontitis
- Participants
- 135 participants
- Comparison
- Intensive periodontal treatment vs control periodontal treatment
- Intensive periodontal treatment (IPT)n = 68
- Control periodontal treatment (CPT)n = 67reference
- Primary endpoint
- Carotid intima-media thickness (cIMT)
- Follow-up
- 24 months
Primary result
cIMT
Difference
−0.023 mm
P < 0.0001
As reported in the abstract
Secondary outcomes
Flow-mediated dilatation (FMD) · from 2 months through study
- Improved within 2 months with IPT and remained consistently higher than CPT
- P < 0.0001
Anthropometric, BP, PWV, metabolomic markers
- No substantial differences between groups
Glycoprotein acetyl
- Reduced with IPT vs CPT
- P < 0.05
Original publication
Periodontitis treatment and progression of carotid intima-media thickness: a randomized trial. Eur Heart J. Published 19 August 2025. doi:10.1093/eurheartj/ehaf555
Summarised from the published abstract; every number is checked against it