Perioperative Metabolomic Profiling in Neonatal Cardiac Surgery Identifies a High-Risk Phenotype for Adverse Outcomes
Authors' conclusion
Metabolomic profiling identified phenotypes associated with risk for adverse outcomes after neonatal cardiac surgery. Amino acid catabolism and inflammatory pathways were linked to morbidity, supporting further evaluation of metabolomic biomarkers for perioperative risk stratification and targeted therapeutic intervention.
Study context
- Population
- Neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB)neonates at 3 institutions
- Participants
- 230 neonates
- Comparison
- Metabolomic phenotypes identified by unsupervised clustering, compared for adverse clinical outcomes
- Outcome
- Composite of:
- Morbidity
- Including death
- Extracorporeal membrane oxygenation
- Cardiac arrest
- Renal replacement therapy
- Hepatic injury
- Elevated lactate
- Low cardiac output syndrome
Methodological details3 institutions, plasma samples at preoperative, post-CPB, and 24-hour time points, Boruta feature selection
- 3 institutions
- Plasma samples at preoperative, post-CPB, and 24-hour time points
- Boruta feature selection
Main finding
As reported in the abstract
Further findings
Metabolite quality control
- Metabolites passing quality control
- Fifty-one of 76
Metabolic pathways and clinical outcomes
- Multiple comparison adjustments confirmed associations between these metabolic pathways and clinical outcomes
Original publication
Perioperative Metabolomic Profiling in Neonatal Cardiac Surgery Identifies a High-Risk Phenotype for Adverse Outcomes. JACC Adv. doi:10.
Summarised from the published abstract; every number is checked against it