Aortic & peripheral vascular diseaseMeta-analysis
Peripheral Artery Disease and Atrial Fibrillation
- systematic review and meta-analysis of observational studies
Authors' conclusion
Data from observational studies suggest that PAD may be associated with a 34% increased risk of NOAF. In patients diagnosed with PAD (ie, low ABI), proactive management of common atherosclerotic risk factors may be considered to potentially reduce the risk of NOAF.
Study context
- Population
- Patients with peripheral artery disease (PAD)7 studies, 56,207 with PAD, 26,064 new-onset atrial fibrillation (NOAF) events
- Participants
- 763,919 patients
- Comparison
- risk of NOAF in PAD patients
- PADn = 56,207
Pooled result
NOAF (pooled)
Hazard ratio
1.34
95% CI 1.18–1.50
PAD vs No PAD
HR 1.34 (95% CI 1.18–1.50)
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| NOAF, PAD defined by ABI<1.0 (subgroup) · I2 = 37% | 1.18 (1.09–1.28) | P < 0.001 | |
| NOAF, ABI>1.4 (subgroup) · I2 = 33%; did not reach statistical significance | 1.14 (0.99–1.32) | P = 0.07 | |
| NOAF, clinically overt PAD (International Classification of Diseases-Ninth Revision or clinical history) (subgroup) · I2 = 81% | 1.40 (1.19–1.66) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Certainty of evidence (GRADE)
- Certainty of the evidence according to GRADE
- low
Original publication
Peripheral Artery Disease and Atrial Fibrillation. JACC Adv. Published 7 August 2026. doi:10.1016/j.jacadv.2026.103111
Summarised from the published abstract; every number is checked against it