Heart failure & cardiomyopathiesCohort study
Peripheral vs. central arterial stiffness and cardiovascular events in older adults: the Atherosclerosis Risk in Communities study
- Prospective cohort study
Authors' conclusion
faPWV showed a borderline significant inverse association with CVD, and cf-fa ratio appeared more strongly associated with CVD than cfPWV.
Study context
- Population
- Older ARIC participants without prior coronary heart disease (CHD), heart failure (HF) or stroke at Visit 5 (2011–13); mean age 74.8 years607 cardiovascular disease (CVD) events
- Participants
- 3,402 participants
- Exposure
- Peripheral vs central arterial stiffness, top vs bottom quartile
- Outcome
- CVD (CHD, HF and stroke)
- Follow-up
- median 9.0-year follow-up
Main finding
As reported in the abstract
CVD
HRP value
faPWV top quartile vs faPWV bottom quartileModel 1 (demographically adjusted)
0.80(95% CI 0.64–1.01)
p-for-trend 0.017faPWV top quartile vs faPWV bottom quartileModel 2 (further adjusted for CVD risk factors)
0.86(CI 0.68–1.09)
p-for-trend 0.096cfPWV top quartile vs cfPWV bottom quartileModel 2
1.22(CI 0.95–1.56)
P = 0.043for trendcf-fa ratiostronger association than cfPWV
1.37(CI 1.07–1.74)
P = 0.005for trendObservational data: associations, not effects.
Further findings
CVD subtypes
- Only significant contrast in Model 2: cf-fa ratio and HF
Original publication
Peripheral vs. central arterial stiffness and cardiovascular events in older adults: the Atherosclerosis Risk in Communities study. Eur J Prev Cardiol. Published 28 August 2025. doi:10.1093/eurjpc/zwaf545
Summarised from the published abstract; every number is checked against it