Coronary disease & ACSCohort study
Periprocedural Myocardial Infarction and Clinical Outcomes in Diffuse versus Focal Coronary Artery Disease
- registry analysis
Authors' conclusion
PMI occurred more frequently after PCI for vessels with diffuse than focal coronary physiology, particularly phenotypes with higher troponin elevation or angiographic complications. Associations with 1-year TVF were observed only for PMI phenotypes incorporating angiographic complications; however, findings should be interpreted cautiously because TVF events were sparse.
Study context
- Population
- Patients undergoing PCI in the pullback pressure gradient (PPG) Global registry, treated vessels classified as focal or diffuse by pullback pressure gradient (PPG)patients undergoing PCI
- Participants
- 855 patients
- Exposure
- diffuse vs focal
- Outcome
- target vessel failure (TVF), a composite of cardiac death, spontaneous target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization
- Follow-up
- 1-year
Main finding
As reported in the abstract
Target vessel failure (TVF) occurred within 1 year
17
Observational data: associations, not effects.
Further findings
Fourth UDMI PMI
Troponin elevation ≥70 × URL
PMI with flow-limiting angiographic complications
PMI with ischemic electrocardiographic changes
- Fourth Universal Definition of Myocardial Infarction (UDMI) periprocedural myocardial infarction (PMI): p=0.048
- Troponin elevation ≥70 × URL: p=0.041
- PMI with flow-limiting angiographic complications: p=0.015
- PMI with ischemic electrocardiographic changes: p=1.000
Original publication
Summarised from the published abstract; every number is checked against it