Heart failure & cardiomyopathiesCohort study
Peroxiredoxin-4, a Marker of Systemic Oxidative Stress, is Associated with Incident Heart Failure
- Prospective cohort study
- community-based
Authors' conclusion
Circulating Prx4 associates with the risk of developing HF, both with preserved and reduced ejection fraction.
Study context
- Population
- Community-based cohort (PREVEND); mean age 49.8 years, 50.1% womenPREVEND cohort
- Participants
- 8,199 participants
- Exposure
- Higher vs lower circulating Prx4
- Outcome
- Incident HF and its subtypes (HFpEF, HFrEF)
- Follow-up
- Median 12.6 years
Main finding
Incident HF
HR per 1 SD increase in log-Prx4
1.22
95% CI 1.09–1.36
P < 0.001
Higher vs lower circulating Prx4 (per 1 SD increase in log-Prx4)
HR per 1 SD increase in log-Prx4 1.22 (95% CI 1.09–1.36); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incident heart failure (HF) by subtype (HFpEF, HFrEF)
| Comparison | HR (95% CI) | |
|---|---|---|
| Prx4 · HFpEF | 1.27 (1.05–1.53) | |
| Prx4 · HFrEF | 1.19 (1.04–1.37) | |
| 0.512Hazard ratio (log scale) |
- Incident HF by subtype (HFpEF, HFrEF) — HFpEF events
- 118 (33.8%)
- Incident HF by subtype (HFpEF, HFrEF) — No significant difference between subtypes
- p = 0.64
Original publication
Peroxiredoxin-4, a Marker of Systemic Oxidative Stress, is Associated with Incident Heart Failure. Eur J Heart Fail. Published 6 April 2025. doi:10.1002/ejhf.3653
Summarised from the published abstract; every number is checked against it