Heart failure & cardiomyopathiesCohort study
Persistent atrial myopathy despite ventricular recovery: prognostic significance of discordant left ventricular (LV)–left atrium (LA) strain patterns in HFrEF
- Registry-based cohort study
- multicentre
Authors' conclusion
In HFrEF patients treated with ARNI-based therapy, persistent LA dysfunction despite LV functional improvement identifies a high-risk phenotype comparable to concordant non-recovery.
Study context
- Population
- HFrEF patients on ARNI-based therapy with serial echocardiography at baseline and 1-year follow-up (STRATS-HF-ARNI registry)
- Participants
- 1,182 patients
- Exposure
- Discordant vs concordant LV–LA strain recovery patterns at 1 year
- Outcome
- All-cause mortality, CV mortality and HF hospitalization
Main finding
As reported in the abstract
All-cause mortality, CV mortality, HF hospitalization
Each group vs group AAdjusted hazard ratio (95% CI)
Group Ball-cause mortality
3.53(1.60–7.79)
Group BCV mortality
5.68(1.91–16.92)
Group CHF hospitalization
2.25(1.31–3.86)
Observational data: associations, not effects.
Further findings
Group B prognosis across subgroups by baseline LVGLS and LASr
- Adverse prognostic impact of discordant atrial non-recovery consistently observed across subgroups
Original publication
Persistent atrial myopathy despite ventricular recovery: prognostic significance of discordant LV–LA strain patterns in HFrEF. Eur J Heart Fail. Published 19 August 2026. doi:10.1093/ejhf/xuag266
Summarised from the published abstract; every number is checked against it