Heart failure & cardiomyopathies
Personalized cardiac resynchronization therapy guided by real-time electrocardiographic imaging for patients with non–left bundle branch block
Authors' conclusion
ECGi-guided CRT implantation in patients with non-LBBB generates superior acute electrical resynchronization compared with BVP and is associated with favorable clinical and echocardiographic outcomes.
Study context
- Population
- HF patients with left ventricular ejection fraction (LVEF) ≤ 35%, QRS ≥ 120 ms and non-LBBB (13 RBBB, 7 intraventricular conduction delay)
- Participants
- 20 patients
- Exposure
- Electrocardiographic imaging (ECGi)-guided personalised cardiac resynchronization therapy (CRT) vs biventricular pacing (BVP)
Main finding
As reported in the abstract
LVEF improved from 26% ± 6% to 34% ± 11%
P < .01
NYHA class improved from 3.0 ± 0.5 to 2.0 ± 0.6
P < .01
Clinical response rate (≥1 NYHA class improvement)
70%
Echocardiographic response rate (LVESV reduction ≥ 15% and/or LVEF improvement ≥ 10%)
70%
Observational data: associations, not effects.
Further findings
Acute TAT reduction
P < 0.01
% total activation time (TAT) reduction as predictor of echocardiographic response
- AUC
- 0.91 (95% CI 0.78-1.00)
- Correlation of % TAT reduction with % LVEF improvement (Pearson R = 0.70)
- P = 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it