Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: A Randomized Pragmatic Trial
Authors' conclusion
Text message reminders targeting patients who delay refilling their cardiovascular medications did not improve medication adherence based on pharmacy refill data or reduce clinical events at 12 months.
Study context
- Population
- Adults (18 to <90 years) with ≥1 CV condition on medication, nonadherent (7-day refill gap)enrolled
- Participants
- 9,501 adults
- Comparison
- Text message refill reminders vs usual care
- Primary endpoint
- Refill adherence (proportion of days covered, pharmacy data)
- Follow-up
- 12 months
Methodological detailspragmatic, patient-level randomisation, 3 US health care systems
- Pragmatic
- Patient-level randomisation
- 3 US health care systems
Primary result
As reported in the abstract
Proportion of days covered
Each group vs usual careDifference, percentage points (95% CI)P value
Generic reminder
2.2(0.3–4.2)
P = 0.02Behavioral nudge
2.0(0.1–3.9)
P = 0.04Behavioral nudge + chatbot
2.3(0.4–4.2)
P = 0.02Secondary outcomes
Clinical events (ED visits, hospitalizations, mortality)
- No differences in clinical events between study groups
Original publication
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: A Randomized Pragmatic Trial. JAMA. Published 7 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it