Arrhythmias & electrophysiologyRandomised controlled trial
Personalized pulmonary vein isolation with very high-power short-duration lesions guided by left atrial wall thickness: the QDOT-by-LAWT randomized trial
- Randomised controlled trial
- 1:1 randomisation
Authors' conclusion
LAWT-guided PVI combining vHPSD and standard-power ablation is not inferior to the CLOSE protocol in terms of 1-year atrial arrhythmia-free survival and demonstrated a reduction in procedural and RF times.
Study context
- Population
- Consecutive patients referred for first-time paroxysmal AF ablation
- Participants
- 162 patients
- Comparison
- Left atrial wall thickness (LAWT)-guided very high-power short-duration (vHPSD) pulmonary vein isolation (PVI) vs CLOSE protocol
- Primary endpoint
- Atrial arrhythmia-free survival
- Follow-up
- 12 months
Primary result
As reported in the abstract
No significant difference in atrial arrhythmia-free survival between groups
P = 0.88
Further findings
Procedure time
P < 0.001
RF time
P < 0.001
First-pass isolation
- No difference between groups
- P = 0.99
Safety
Complication rate
- No difference between groups
- P = 0.99
Original publication
Personalized pulmonary vein isolation with very high-power short-duration lesions guided by left atrial wall thickness: the QDOT-by-LAWT randomized trial. Europace. Published 23 April 2024. doi:10.1093/europace/euae087
Summarised from the published abstract; every number is checked against it