Heart failure & cardiomyopathiesCohort study
Pharmacist Management and Quality of Care for Heart Failure With Reduced Left Ventricular Ejection Fraction
- Retrospective cohort study
Authors' conclusion
Pharmacist management was associated with increased guideline-recommended medication use.
Study context
- Population
- Patients with recent-onset Heart Failure with Reduced Ejection Fraction (HFrEF) (EF ≤40%) in the VA Health Care System, 2017–2021
- Participants
- 104,517 patients
- Exposure
- Pharmacist encounter vs no pharmacist encounter
- Pharmacist encountern = 10,657
- Outcome
- Optimal guideline-recommended medication (RAS inhibitors, beta-blocker and MRA where no contraindications)
- Follow-up
- 12 months after incident HFrEF diagnosis
Main finding
As reported in the abstract
On all recommended therapy (patients without contraindications)
Adjusted odds ratio
2.51
95% CI 2.39–2.63
P < 0.0001
By group
Pharmacist encounter vs No pharmacist encounter
adjusted OR 2.51 (95% CI 2.39–2.63); P < 0.0001
Observational data: associations, not effects.
Further findings
Use of individual treatments
ARNI
Beta-blocker
MRA
- Use of individual treatments: all P < 0.0001
Pharmacist encounter within 6 months of diagnosis, by year
- 2017
- 7.0%
- 2021
- 14.3%
Original publication
Pharmacist Management and Quality of Care for Heart Failure With Reduced Left Ventricular Ejection Fraction. JACC Heart Fail. Published 25 July 2025. doi:10.1016/j.jchf.2025.102530
Summarised from the published abstract; every number is checked against it