Coronary disease & ACSCohort study
Pharmacodynamic effects of cangrelor in patients with or without ST elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention: insights from the POMPEII study
- investigator-initiated, prospective study
- registry
Authors' conclusion
Cangrelor-induced platelet inhibition was lower in patients with STEMI compared with those without STEMI and was lower than that induced by ticagrelor among STEMI patients. The switch from cangrelor to an oral P2Y12 inhibitor exposed patients without STEMI to greater HRPR compared with those with STEMI.
Study context
- Population
- Patients naïve from oral P2Y12 inhibitors undergoing percutaneous coronary intervention (PCI) with cangrelor, with or without STEMIpatients naïve from oral P2Y12 inhibitors who underwent PCI with cangrelor, March 2021 to June 2024 · STEMI 32 · without STEMI 94 · NSTE-ACS 30 · CCS 64
- Participants
- 126 participants
- Exposure
- patients with STEMI compared with those without STEMI
- STEMIn = 32
- without STEMIn = 94
Main finding
As reported in the abstract
Inhibition of platelet aggregation (IPA%) during cangrelor infusion (LTA 20-μM-ADP) · during cangrelor infusion
P = 0.017
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Within STEMI patients, cangrelor-induced IPA vs ticagrelor-induced IPA · cangrelor-induced IPA was lower | P = 0.036 |
IPA after switching from cangrelor to an oral P2Y12 inhibitor
- IPA was greater in patients with STEMI compared with those without STEMI
Rates of high residual platelet reactivity (HRPR)
- consistent with lower platelet inhibition in STEMI during cangrelor and greater after its discontinuation compared with patients without STEMI
Original publication
Pharmacodynamic effects of cangrelor in patients with or without STEMI undergoing percutaneous coronary intervention: insights from the POMPEII study. Eur Heart J Acute Cardiovasc Care. Published 15 April 2026. doi:10.1093/ehjacc/zuag056
Summarised from the published abstract; every number is checked against it