Acute cardiac care & resuscitationDiagnostic or prognostic study
Phenotypes of cardiogenic shock after out-of-hospital cardiac arrest: the SCAI-V classification
- retrospective analysis of an international derivation cohort and external validation
- 2x2 factorial framework
Authors' conclusion
The SCAI-V classification enhances phenotypic profiling of CS after resuscitated OHCA and may improve patient selection for early invasive therapies in this population.
Study context
- Population
- Patients with cardiogenic shock after resuscitated out-of-hospital cardiac arrestderivation cohort (London, United Kingdom; GdaÅsk, Poland) 627 · TTM-2 trial cohort (validation) 1,781
- Comparison
- SCAI-V classification vs the 2019 and 2022 SCAI classifications
- Outcome
- Mortality
- Follow-up
- Hospital discharge (derivation cohort) or 180 days (TTM-2 cohort)
Performance
As reported in the abstract
| Outcome | non-shock | systemic ischaemia | haemodynamic shock | haemometabolic shock |
|---|---|---|---|---|
| derivation | Not reported in the abstract | Not reported in the abstract | 60% | 20% |
| validation | Not reported in the abstract | Not reported in the abstract | 51% | 27% |
- SCAI-V classification associated with all-cause and non-neurological mortality
- P < 0.001
Secondary outcomes
Derivation cohort characteristics
- median age, years (interquartile range 53-74)
- 63
- male
- 76%
- discordant haemodynamic parameters and lactate levels with SCAI classification (SCAI-2022)
- 60%
Model performance
- Derivation: SCAI-V superior model fit, discrimination, and calibration than the 2019 and 2022 SCAI classifications
- TTM-2: consistent model fit advantages and discrimination comparable to SCAI-2022
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Phenotypes of cardiogenic shock after out-of-hospital cardiac arrest: the SCAI-V classification. EuroIntervention. Published 21 September 2026. doi:10.4244/eij-d-26-00092
Summarised from the published abstract; every number is checked against it