Acute cardiac care & resuscitation
Phenotypes of cardiogenic shock after out-of-hospital cardiac arrest: the SCAI-V classification
Authors' conclusion
The SCAI-V classification enhances phenotypic profiling of CS after resuscitated OHCA and may improve patient selection for early invasive therapies in this population.
Study context
- Population
- Patients with cardiogenic shock after resuscitated out-of-hospital cardiac arrestderivation cohort (London, United Kingdom; GdaÅsk, Poland) 627 · TTM-2 trial cohort (validation) 1,781
- Comparison
- SCAI-V classification vs the 2019 and 2022 Society for Cardiovascular Angiography and Interventions (SCAI) classifications
- Outcome
- Mortality
- Follow-up
- Hospital discharge (derivation cohort) or 180 days (TTM-2 cohort)
Methodological details2x2 factorial framework
- 2x2 factorial framework
Performance
As reported in the abstract
| Outcome | Haemodynamic shock | Haemometabolic shock |
|---|---|---|
| Derivation | 60% | 20% |
| Validation | 51% | 27% |
- SCAI-V classification associated with all-cause and non-neurological mortality
- P < 0.001
Secondary outcomes
Derivation cohort characteristics
- Median age, years (interquartile range 53-74)
- 63
- Male
- 76%
- Discordant haemodynamic parameters and lactate levels with SCAI classification (SCAI-2022)
- 60%
Model performance
- Derivation: SCAI-V superior model fit, discrimination, and calibration than the 2019 and 2022 SCAI classifications
- TTM-2: consistent model fit advantages and discrimination comparable to SCAI-2022
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Phenotypes of cardiogenic shock after out-of-hospital cardiac arrest: the SCAI-V classification. EuroIntervention. Published 21 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →