Heart failure & cardiomyopathiesCohort study
Phenotypic Expression and Clinical Outcomes in Patients With Arrhythmogenic Cardiomyopathies
- Cohort study
Authors' conclusion
The comparison of ACM phenotypes demonstrated that patients with right ventricular involvement, such as ARVC and BIV forms, exhibit a higher incidence of life-threatening ventricular arrhythmias. Conversely, ACM forms characterized by left ventricular involvement, such as ALVC and BIV, show a higher incidence of heart failure, heart transplantation, and hot phases.
Study context
- Population
- Patients diagnosed with arrhythmogenic cardiomyopathy (ACM)
- Participants
- 446 patients
- Exposure
- ACM phenotypes: Arrhythmogenic right ventricular cardiomyopathy (ARVC) vs arrhythmogenic left ventricular cardiomyopathy (ALVC) vs BIV
Main finding
As reported in the abstract
Outcomes by ACM phenotype
Share of patients
- Life-threatening ventricular arrhythmias more frequent with ARVC and BIV vs ALVC
- P < 0.001
- HF, heart transplantation and cardiac death more frequent with BIV vs ALVC and ARVC
- P < 0.001
- Hot phases more frequent with ALVC vs ARVC and BIV
- P = 0.013
Observational data: associations, not effects.
Original publication
Phenotypic Expression and Clinical Outcomes in Patients With Arrhythmogenic Cardiomyopathies. J Am Coll Cardiol. Published 27 February 2024. doi:10.1016/j.jacc.2023.12.015
Summarised from the published abstract; every number is checked against it