Heart failure & cardiomyopathies
Phenotyping Patients with Ischaemic Heart Disease at Risk of Developing Heart Failure: An Analysis of the HOMAGE Trial
Authors' conclusion
In patients at risk of developing HF, those with CAD or MI had a different proteomic profile regarding inflammatory, immunological, and collagen catabolic processes.
Study context
- Population
- Patients with (or at risk of having) coronary artery disease (CAD) and raised natriuretic peptides, at risk of developing heart failure (HF)
- Participants
- 527 patients
- Comparison
- CAD vs prior myocardial infarction (MI) vs neither CAD nor MI
- Primary endpoint
- Between-group proteomic differences (logistic regression, backward stepwise selection and bootstrapping)
- Follow-up
- Baseline
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
Baseline plasma proteomic profile
Further findings
Effect of spironolactone on proteins · 9 months
- Spironolactone associated with increase of MMP7, NT3 and PGLYRP1
Original publication
Phenotyping Patients with Ischaemic Heart Disease at Risk of Developing Heart Failure: An Analysis of the HOMAGE Trial. ESC Heart Fail. Published 8 November 2023. doi:10.
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