Heart failure & cardiomyopathiesDiagnostic or prognostic study
Photon-Counting Computed Tomography for Tissue Characterization in Patients With a Left Ventricular Hypertrophic Phenotype
- Diagnostic accuracy study
- consecutive patients
- paired photon-counting computed tomography (PCCT) and cardiac magnetic resonance (CMR) in a subset
Authors' conclusion
PCCT provides CMR-comparable assessment of ventricular geometry, function, and myocardial fibrosis/ECV while enabling coronary angiography
Study context
- Population
- Consecutive patients with left ventricular hypertrophy (LVH) undergoing PCCT with late iodine enhancement and PCCT-derived extracellular volume (ECV)83 (46%) also had CMR
- Participants
- 182 patients
- Comparison
- Photon-counting CT vs CMR for tissue characterization of LVH
- Hypertrophic cardiomyopathyn = 72
- Transthyretin cardiac amyloidosisn = 47
- Secondary LVHn = 63
- Outcome
- Agreement of PCCT with CMR for morphofunctional indices, ECV, and LIE vs LGE
Performance
As reported in the abstract
Agreement of PCCT with CMR (paired examinations)
- LV mass index correlation, PCCT vs CMR
- r = 0.963; P < 0.001
- LVEF correlation, PCCT vs CMR
- r = 0.947; P < 0.001
- ECV correlation, PCCT vs CMR
- r = 0.868; P < 0.001
- Late iodine enhancement (LIE) extent vs LGE extent
- r = 0.998; P < 0.001
- Segment-wise LIE/LGE agreement
- 99% to 100%
- Detection of CMR-LGE by PCCT, AUC
- 0.994
- Detection of CMR-LGE by PCCT, sensitivity
- 99%
- Detection of CMR-LGE by PCCT, specificity
- 100%
Further findings
PCCT tissue patterns by aetiology (LV mass index, LIE extent, ECV)
LV mass index Transthyretin cardiac amyloidosis 104 g/m²
LIE extent Hypertrophic cardiomyopathy 4 enhanced segments · Transthyretin cardiac amyloidosis 17/17 segments · Secondary LVH 0 segments
ECV
PCCT tissue patterns by aetiology (LV mass index, LIE extent, ECV)
- PCCT differentiated etiologies through distinctive tissue patterns
Original publication
Photon-Counting Computed Tomography for Tissue Characterization in Patients With a Left Ventricular Hypertrophic Phenotype. JACC Cardiovasc Imaging. Published 1 April 2026. doi:10.1016/j.jcmg.2026.02.019
Summarised from the published abstract; every number is checked against it