Heart failure & cardiomyopathiesCohort study
Physical Activity and Cardiovascular Outcomes in Phenotype-Negative Cardiomyopathy Variant Carriers
- Prospective cohort study
- 22 assessment centres, UK Biobank
Conducted February 2013 to December 2015; analysed March 2024 to June 2025
Authors' conclusion
In this cohort study, MVPA within the general range of guideline-based recommendations was associated with lower risk of adverse CV outcomes and similar degrees of cardiac remodeling for G+P- carriers compared to noncarriers.
Study context
- Population
- UK Biobank participants with whole-genome sequencing and 1 week of accelerometer data, without prevalent heart failure (HF), atrial fibrillation (AF), cardiomyopathy, ventricular arrhythmias (VAs) or ICDs
- Participants
- 84,699 participants
- Exposure
- Higher vs zero accelerometer-measured moderate to vigorous physical activity (MVPA), G+P- carriers vs noncarriers
- G+P- carriersn = 3,979
- Outcome
- Incident adverse CV outcomes (AF, HF, MI, stroke), CMR measures of cardiac remodeling, cardiomyopathy and VA, by MVPA volume
- Follow-up
- Median 8.0 years
Main finding
As reported in the abstract
Incident CV disease in G+P- carriers (optimal MVPA vs zero) · median (IQR) 8.0 (7.5-8.5) years
Optimal MVPA vs Zero MVPAHazard ratio (95% CI)
AF, G+P- carriers
0.68(0.58–0.79)
HF, G+P- carriers
0.58(0.47–0.71)
MI, G+P- carriers
0.49(0.24–1.00)
stroke, G+P- carriers
0.35(0.12–0.99)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) |
|---|---|
| Incident cardiomyopathy in G+P- carriers | 0.03 (0.00–0.98) |
Cardiac magnetic resonance (CMR) cardiac remodeling (eg, LV dilation, LV hypertrophy)
- Similar pattern and extent of remodeling with MVPA in G+P- carriers vs noncarriers
Variant subtypes (DCM, HCM, ARVC)
- Findings generally consistent across variants; limited precision for ARVC
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| VA among G+P- carriers · no increase in risk of VA | 0.98 (0.83–1.14) | |
| 0.512Hazard ratio (log scale) |
Original publication
Physical Activity and Cardiovascular Outcomes in Phenotype-Negative Cardiomyopathy Variant Carriers. JAMA Cardiol. Published 1 January 2026. doi:10.1001/jamacardio.2025.4466
Summarised from the published abstract; every number is checked against it