Prevention & lipidsCohort study
Physical Activity and Progression of Coronary Artery Calcification in Men and Women
- Prospective cohort study
- single-centre
Authors' conclusion
This study found that PA volume was not associated with progression of CAC in a large cohort of healthy men and women who were initially free of overt cardiovascular disease.
Study context
- Population
- Apparently healthy men and women aged ≥40 years with multiple preventive medicine visits at the Cooper Clinic (Dallas, Texas), 1998–2019
- Participants
- 8,771 men
- Exposure
- Higher vs lower physical activity volume
- Outcome
- Rate of mean CAC progression between visits, by PA volume (per 500 MET-min/wk); CAC progression to ≥100 AU by baseline PA
- Follow-up
- Mean (SD) 7.8 (4.7) years
Main finding
As reported in the abstract
CAC progression per year
Per 500 MET-min/wkDifference in rate of CAC progression per year (95% CI)
men
0.0%(−0.1% to 0.1%)
women
0.0%(−0.4% to 0.5%)
Per 500 MET-min/wk, as printed
- Rate of mean coronary artery calcium (CAC) progression per year, men, independent of mean physical activity (PA)
- 28.5%
- Rate of mean CAC progression per year, women, independent of mean PA
- 32.1%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CAC progression to ≥100 AU by baseline PA — ≥3000 MET-min/wk vs <1500 MET-min/wk · men | 0.84 (0.66–1.08) | |
| CAC progression to ≥100 AU by baseline PA — ≥3000 MET-min/wk vs <1500 MET-min/wk · women | 1.16 (0.57–2.35) | |
| 0.512Hazard ratio (log scale) |
CAC progression to ≥100 Agatston units (AU) by baseline PA
- Baseline PA not associated with CAC progression to ≥100 AU
Original publication
Physical Activity and Progression of Coronary Artery Calcification in Men and Women. JAMA Cardiol. Published 1 July 2024. doi:10.1001/jamacardio.2024.0759
Summarised from the published abstract; every number is checked against it