Cardio-oncology & otherCohort study
Physical Activity During Breast Cancer Therapy Associates With Preserved Exercise Capacity and Cardiac Function (WF97415)
- Prospective cohort study
Authors' conclusion
PA declined during BC therapy; however, PA participation was associated with attenuated declines in exercise capacity and cardiac function that are often observed in this population.
Study context
- Population
- Women with stage I–III breast cancer undergoing treatment, and controls
- Participants
- 223 vs 126
- Exposure
- Breast cancer (BC) vs Control
- BCn = 223
- Controln = 126reference
- Outcome
- Submaximal exercise capacity (6-minute walk distance) and cardiac function (CMR) by leisure-time PA
- Follow-up
- 3 months
Main finding
As reported in the abstract
Association of LTPA with exercise capacity and cardiac function (BC participants)
Each group vs controlOdds ratio (95% CI)
Increased LTPA over 3 monthstreatment-induced cardiac dysfunction by LV circumferential strain
0.98(0.97–0.998)
- More Leisure-time PA (LTPA) · exercise capacity
- β ± SE 7.1 ± 1.6 (95% CI 4.0–10.1)
- More LTPA · left ventricular (LV) circumferential strain
- β ± SE −0.16 ± 0.07 (95% CI −0.29 to −0.02)
Observational data: associations, not effects.
Further findings
| Outcome | BC | Control | Estimate | P value |
|---|---|---|---|---|
| LTPA score · baseline | 24.7 (95% CI 21.7–28.0) | 29.4 (95% CI 25.0–34.2) | ||
| LTPA score · 3 months | 16.9 (95% CI 14.4–19.6) | 30.8 (95% CI 26.2–35.8) | ||
| Change in BC participants with insufficient LTPA per PA guidelines — Insufficient LTPA · exercise capacity | adjusted mean difference ± SE −29 ± 10 m | P = 0.029 | ||
| Change in BC participants with insufficient LTPA per PA guidelines — Insufficient LTPA · LV end-systolic volume | adjusted mean difference ± SE 5.8 ± 1.3 mL | P < 0.001 | ||
| Change in BC participants with insufficient LTPA per PA guidelines — Insufficient LTPA · LVEF | adjusted mean difference ± SE −3.2% ± 0.8% | P = 0.002 | ||
| Change in BC participants with insufficient LTPA per PA guidelines — Insufficient LTPA · LV circumferential strain | adjusted mean difference ± SE 2.5% ± 0.5% | P < 0.001 |
LTPA score · baseline
- Similar baseline LTPA scores
Change in BC participants with insufficient LTPA per physical activity (PA) guidelines
- BC participants meeting LTPA guidelines did not exhibit these adverse changes
Original publication
Physical Activity During Breast Cancer Therapy Associates With Preserved Exercise Capacity and Cardiac Function (WF97415). JACC CardioOncol. Published 21 March 2023. doi:10.1016/j.jaccao.2022.12.011
Summarised from the published abstract; every number is checked against it