Valvular & structural heart diseaseRandomised controlled trial
Physiology vs angiography-guided percutaneous coronary intervention in transcatheter aortic valve implantation: the FAITAVI trial
- Randomised controlled trial
- multicentre
- open-label
- superiority
- blind adjudication of adverse events
- 1:1 randomisation
Authors' conclusion
In patients undergoing TAVI with intermediate coronary lesions, FFR-guided PCI was associated with a reduced risk of MACCE at 12 months.
Study context
- Population
- Patients with AS and intermediate coronary lesions undergoing transcatheter aortic valve implantation (TAVI), 15 Italian centres
- Participants
- 320 patients
- Comparison
- Fractional flow reserve (FFR)-guided vs angiography-guided percutaneous coronary intervention (PCI)
- Primary endpoint
- MACCE:
- All-cause death
- MI
- Ischaemia-driven target vessel revascularization
- Disabling stroke
- Major bleeding
- Follow-up
- 12 months
Primary result
MACCE
Hazard ratio
.52
95% CI .27-.99
P = 0.047
By group
As reported in the abstract
Further findings
| Outcome | HR (95% CI) |
|---|---|
| All-cause mortality (MACCE component) | .31 (.10-.96) |
Other major adverse cardiac and cerebrovascular event (MACCE) components
- Numerically lower but not statistically significant
Original publication
Physiology vs angiography-guided percutaneous coronary intervention in transcatheter aortic valve implantation: the FAITAVI trial. Eur Heart J. Published 19 December 2025. doi:10.1093/eurheartj/ehaf974
Summarised from the published abstract; every number is checked against it