Heart failure & cardiomyopathiesCohort study
Plasma Ferritin Levels, Incident Heart Failure, and Cardiac Structure and Function
- Prospective cohort study
- longitudinal
- fully adjusted Cox proportional hazards models
Authors' conclusion
Among older adults without prevalent HF or anemia, lower plasma ferritin level is associated with a higher risk for incident HF, HFpEF, and higher measures of left ventricular filling pressure.
Study context
- Population
- Older adults in the ARIC study free of prevalent heart failure (HF) and anemiamean age 75 ± 5 years
- Participants
- 3,472 adults
- Exposure
- Lower vs higher plasma ferritin level
- Outcome
- Incident HF overall, heart failure with preserved ejection fraction (HFpEF) and HFrEF; echocardiographic cardiac structure and function
Main finding
As reported in the abstract
Incident HF per 50% lower ferritin
Hazard ratio (95% CI)
50% lower ferritinincident HF overall; fully adjusted
1.20(1.08–1.34)
Lower ferritinincident HFpEF; fully adjusted
1.28(1.09–1.50)
Per 50% lower ferritin, as printed
Observational data: associations, not effects.
Further findings
Echocardiographic cardiac structure and function (cross-sectional)
- Lower ferritin associated with higher E/e' ratio and higher pulmonary artery systolic pressure
- No association with LV structure or systolic function
- adjusted for demographics and HF risk factors
Original publication
Plasma Ferritin Levels, Incident Heart Failure, and Cardiac Structure and Function. JACC Heart Fail. Published 10 January 2024. doi:10.1016/j.jchf.2023.11.009
Summarised from the published abstract; every number is checked against it