Prevention & lipidsResearch article
Plasma heart-type fatty acid-binding protein, omega-3 fatty acids and adverse cardiac events in the general population
- Multivariable Cox regression in the UK Biobank
Authors' conclusion
Higher plasma levels of H-FABP were associated with a higher risk of CHD and HF in the general population, predominantly among individuals with low levels of omega-3 FAs.
Study context
- Population
- UK Biobank participants free of coronary heart disease (CHD) and heart failure (HF) at baseline
- Participants
- 42,392 participants
- Comparison
- associations of H-FABP with incident CHD and HF, considering potential interaction with omega-3 fatty acids (FAs)
Main finding
As reported in the abstract
CHD, MI, CHD-related mortality and HF
- CHD
- HR 1.29; P-trend values <0.001
- Myocardial infarction (MI)
- HR 1.54; P-trend values <0.001
- CHD-related mortality
- HR 2.04; P-trend values <0.001
- HF
- HR 1.95; P-trend values <0.001
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CHD and MI by plasma omega-3 FAs (effect modification) — T3 vs T1 · CHD, lower omega-3 FAs | 1.41 (1.15–1.74) | |
| CHD and MI by plasma omega-3 FAs (effect modification) — T3 vs T1 · MI, lower omega-3 FAs | 2.23 (1.57–3.15) | |
| CHD and MI by plasma omega-3 FAs (effect modification) — T3 vs T1 · CHD, higher omega-3 FAs | 1.15 (0.96–1.38) | |
| CHD and MI by plasma omega-3 FAs (effect modification) — T3 vs T1 · MI, higher omega-3 FAs | 1.11 (0.83–1.50) | |
| 0.20.5125Hazard ratio (log scale) |
- CHD and MI by plasma omega-3 FAs (effect modification): P-interaction=0.014 (CHD)
- CHD and MI by plasma omega-3 FAs (effect modification): P-interaction=0.003 (MI)
Original publication
Plasma heart-type fatty acid-binding protein, omega-3 fatty acids and adverse cardiac events in the general population. Heart. Published 1 October 2026. doi:10.1136/heartjnl-2026-327893
Summarised from the published abstract; every number is checked against it